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Table of Contents > Drug > Chlorhexidine Gluconate Print

Chlorhexidine Gluconate


Related terms
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    Related terms
    • U.S. Brand Names: AvagardT [OTC];Bactoshield® CHG [OTC];Betasept® [OTC];ChloraPrep® Frepp® [OTC];ChloraPrep® Sepp® [OTC];ChloraPrep® [OTC];ChlorascrubT Maxi [OTC];ChlorascrubT [OTC];Dyna-Hex® [OTC];Hibiclens® [OTC];Hibistat® [OTC];Operand® Chlorhexidine Gluconate [OTC];Peridex®;PerioChip®;PerioGard® [OTC]
    • Canadian Brand Names: Hibidil® 1:2000;ORO-Clense;Peridex® Oral Rinse
    • Mexican Brand Names: Perioxidin
    • Pharmacologic Category: Antibiotic, Oral Rinse;Antibiotic, Topical

    • This medicine is used to prevent and treat mouth infections.
    • This medicine is used to clean the skin.
    • Chlorhexidine gluconate works to injure the bacteria and fight the infection.


    How to take

    • Oral rinse:
    • Brush and floss teeth.
    • Rinse with 1 tablespoon of medicine for 30 seconds.
    • Do not swallow medicine.
    • Rinse twice daily in the morning and in the evening.
    • Wait 30 minutes before eating, drinking, using mouthwash, or brushing teeth.
    • Oral chip:
    • Your healthcare provider will give this medicine.
    • Do not floss the area where the chip was placed for 10 days.
    • Skin (cleanser):
    • Do not take this medicine by mouth. For skin only. Keep out of mouth, nose, ears, and eyes (may burn).
    • Skin (hand sanitizer):
    • Work under fingertips.
    • Spread over hand and to just above elbow.
    • Apply another pump full to both hands and spread over hands and up to the wrist.
    • Rub into hands until dry.
    • Skin (hand washing):
    • Wet hands and forearms.
    • Apply 1 teaspoon to hands and wash for 1 minute.
    • Rinse affected area with water. Make sure to dry well.
    • Skin (before surgery):
    • Your healthcare provider may teach you how to use.
    • Your healthcare provider may apply to skin.
    • Skin (surgical wash):
    • Your healthcare provider will give this medicine.

    Missed Dose

    • Use a missed dose as soon as possible.
    • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
    • Many times this medicine is used on an as needed basis.


    • Store at room temperature.
    • Protect from heat.



    • If you have an allergy to chlorhexidine gluconate or any other part of this medicine.
    • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.


    • All forms:
    • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
    • Tell healthcare provider if you are pregnant or plan on getting pregnant.
    • Tell healthcare provider if you are breast-feeding.
    • Oral:
    • If you have front-tooth fillings or other gum problems, talk with healthcare provider.
    • Skin:
    • Protect clothing and fabrics from staining.

    Side Effects

    • Oral:
    • Mouth and lip irritation. Frequent mouth care with a soft toothbrush or cotton swabs and rinsing mouth may help.
    • Abnormal taste. This is usually reversible.
    • Skin:
    • Dryness.
    • Skin irritation.


    • Oral:
    • Change in condition being treated. Is it better, worse, or about the same?

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or emergency department immediately.
    • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Severe skin irritation.
    • Any rash.
    • Oral:
    • Severe gum irritation or swelling.
    • Numbness or tingling around mouth.
    • Staining of mouth, teeth, or fillings.
    • No improvement in condition or feeling worse.

    General Statements

    • If you have a life-threatening allergy, wear allergy identification at all times.
    • Do not share your medicine with others and do not take anyone else's medicine.
    • Keep all medicine out of the reach of children and pets.
    • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
    • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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